Acquired resistance to selective FGFR inhibitors in FGFR-altered cholangiocarcinoma
نویسندگان
چکیده
منابع مشابه
Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.
Genetic alterations in the fibroblast growth factor receptor (FGFR) pathway are promising therapeutic targets in many cancers, including intrahepatic cholangiocarcinoma (ICC). The FGFR inhibitor BGJ398 displayed encouraging efficacy in patients with FGFR2 fusion-positive ICC in a phase II trial, but the durability of response was limited in some patients. Here, we report the molecular basis for...
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ژورنال
عنوان ژورنال: European Journal of Cancer
سال: 2020
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(20)31121-7